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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name 10-Gingerol, Paclitaxel
Phytochemical Name 10-Gingerol (PubChem CID: 168115 )
Anticancer drug Name Paclitaxel (PubChem CID: 36314 )
Structure of
Phytochemical
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Structure of
Anticancer Drug
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 485
Pair Name 10-Gingerol, Paclitaxel
Disease Info [ICD-11: 2C60] Breast cancer Investigative
Gene Regulation Down-regulation Expression ADRB2 hsa154
Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Down-regulation Expression MAPK1 hsa5594
Up-regulation Cleavage PARP1 hsa142
In Vitro Model MDA-MB-231 Breast adenocarcinoma Homo sapiens (Human) CVCL_0062
SUM159PT Breast pleomorphic carcinoma Homo sapiens (Human) CVCL_5423
In Vivo Model Human MDA-MB-231 cells (cell density: 5×10⁶ / 200 μL PBS) were injected into the breast fat pad of each mouse.
Result This data suggests that 10-G may be used as a new chemotherapeutic synergist in combination with paclitaxel to enhance anticancer activity. The potential value of ADRB2 as a target for improving chemotherapy sensitivity was also emphasized.
03. Reference
No. Title Href
1 10-Gingerol Enhances the Effect of Taxol in Triple-Negative Breast Cancer via Targeting ADRB2 Signaling. Drug Des Devel Ther. 2023 Jan 20;17:129-142. doi: 10.2147/DDDT.S390602. Click
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