Pair Name | 10-Gingerol, Paclitaxel | ||
Phytochemical Name | 10-Gingerol (PubChem CID: 168115 ) | ||
Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
Structure of Phytochemical |
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MOL
3D
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Pair Name | 10-Gingerol, Paclitaxel | |||
Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
Gene Regulation | Down-regulation | Expression | ADRB2 | hsa154 |
Up-regulation | Expression | BAX | hsa581 | |
Down-regulation | Expression | BCL2 | hsa596 | |
Down-regulation | Expression | MAPK1 | hsa5594 | |
Up-regulation | Cleavage | PARP1 | hsa142 | |
In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
SUM159PT | Breast pleomorphic carcinoma | Homo sapiens (Human) | CVCL_5423 | |
In Vivo Model | Human MDA-MB-231 cells (cell density: 5×10⁶ / 200 μL PBS) were injected into the breast fat pad of each mouse. | |||
Result | This data suggests that 10-G may be used as a new chemotherapeutic synergist in combination with paclitaxel to enhance anticancer activity. The potential value of ADRB2 as a target for improving chemotherapy sensitivity was also emphasized. |
No. | Title | Href |
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1 | 10-Gingerol Enhances the Effect of Taxol in Triple-Negative Breast Cancer via Targeting ADRB2 Signaling. Drug Des Devel Ther. 2023 Jan 20;17:129-142. doi: 10.2147/DDDT.S390602. | Click |